Fetal Cardiac Troponin Isoforms Rescue the Increased Ca Sensitivity Produced by a Novel Double Deletion in Cardiac Troponin T Linked to Restrictive Cardiomyopathy. A Clinical, Genetic and Functional Approach

Fetal Cardiac Troponin Isoforms Rescue the Increased Ca Sensitivity Produced by a Novel Double Deletion in Cardiac Troponin T Linked to Restrictive Cardiomyopathy. A Clinical, Genetic and Functional Approach. Jose Renato Pinto, Shi Wei Yang, Marc-Phillip Hitz, Michelle S. Parvatiyar, Michelle A. Jones, Jingsheng Liang, Victor Kokta, Mario Talajic, Nicolas Tremblay , Michelle Jaeggi, Gregor Andelfinger and James D. Potter 1 University of Miami Miller School of Medicine, 1600 NW 10 Ave. Miami, FL 33136 United States 2 Génétique Cardiovasculaire, CHU Sainte Justine, Departments of Pediatrics and Biochemistry, University of Montréal, 3175, Côte Sainte Catherine, Montréal, Québec H3T 1C5 Canada 3 Montreal Heart Institute, Department of Medicine, University of Montréal, Montréal, Québec, Canada 4 These two authors contributed equally to the manuscript. 5 These are co-corresponding authors Running Head: A Novel RCM Double Deletion in TNNT2 Address correspondence to: James D. Potter, Ph.D., Department of Molecular and Cellular Pharmacology, University of Miami, Miller School of Medicine, Room 6083 (R-189), 1600 NW 10th Avenue, Miami, FL, USA 33136. E-mail address: [email protected] or Gregor Andelfinger, M.D., Génétique Cardiovasculaire, CHU Sainte Justine, University of Montreal, 3175, Côte Sainte Catherine, Montréal, Québec H3T 1C5 Canada . E-mail address: [email protected]